Products Description
Cimetidine acts as an H2‑receptor antagonist. It powerfully suppresses gastric acid secretion stimulated by food, histamine and pentagastrin, and reduces gastric acidity. The compound delivers preventive and protective effects against chemically‑induced corrosive gastritis, and exhibits favorable efficacy for stress‑related gastric ulcers as well as upper gastrointestinal hemorrhage. Possessing anti‑androgenic properties, it shows partial therapeutic value in managing hirsutism. Furthermore, it attenuates the activity of immunosuppressive cells to elevate immune responses, which may inhibit tumor progression and prolong survival. Clinically, it is applied for the treatment of duodenal ulcers, gastric ulcers, upper gastrointestinal bleeding and other relevant disorders.
Products Chemical Properties
| Melting point | 139-144°C |
| Boiling point | 476.2±55.0 °C(Predicted) |
| density | 1.2583 (rough estimate) |
| refractive index | 1.5700 (estimate) |
| storage temp. | 2-8°C |
| solubility | Slightly soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute mineral acids. |
| form | Solid |
| pka | pKa 6.80 (Uncertain) |
| color | White to Off-White |
| Water Solubility | 0.5 g/100 mL at 20 ºC |
| Merck | 142279 |
| InChIKey | AQIXAKUUQRKLND-UHFFFAOYSA-N |
| CAS DataBase Reference | 51481-61-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Cimetidine(51481-61-9) |
| IARC | 3 (Vol. 50) 1990 |
| EPA Substance Registry System | Guanidine, N-cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]- (51481-61-9) |
Safety Information | |
| Hazard Codes | T,Xn |
| Risk Statements | 60-42/43-36/37/38-20/22 |
| Safety Statements | 53-26-36/37/39-45-36-22 |
| WGK Germany | 3 |
| RTECS | MF0035500 |
| HS Code | 29339900 |
| Hazardous Substances Data | 51481-61-9(Hazardous Substances Data) |
| Toxicity | LD50 in mice, rats (mg/kg): 2600, 5000 orally; 150, 106 i.v.; 470, 650 i.p. (Brimblecombe) |
Products Application
Cimetidine, first launched commercially in 1975, represents the original selective H2‑receptor antagonist developed for the treatment of peptic ulcer disease. Its core function lies in suppressing gastric acid secretion and lowering gastric acidity, which confers protective and preventive benefits against chemically provoked corrosive gastritis. It also achieves prominent therapeutic effects on stress‑provoked gastric ulcers and upper gastrointestinal hemorrhage.
As a histamine H2‑receptor antagonist, cimetidine suppresses gastric acid secretion stimulated by histamine, alongside secretory responses triggered by food, pentagastrin, caffeine and insulin. It further reduces basal gastric acid output, rendering it suitable for managing gastric ulcers, duodenal ulcers, peptic esophagitis and Zollinger‑Ellison syndrome.
In addition to its well‑documented applications for peptic ulcer disorders, cimetidine functions as an H2 histamine receptor antagonist, an I1‑imidazoline receptor agonist and an anti‑ulcer agent. It impedes cancer cell metastasis by down‑regulating endothelial selectin expression, consequently interfering with tumor‑cell adhesion.
Company Profile
Shandong Furuida Chemical Co., Ltd. is a global start-up chemical foreign trade enterprise located in the core chemical industrial zone of Shandong Province. The company’s operations are built around self-owned standardized factories that integrate production, quality control, cross-border trade, and global logistics into a cohesive system.
The company’s product offering includes basic chemical raw materials, fine chemical intermediates, chemical additives, and rubber and plastic feedstocks. These materials are used across the rubber, plastics, coatings, daily chemicals, building materials, and textile industries. The company further distinguishes itself through the provision of customized product formulations and a one-stop service package that covers customs clearance, logistics management, and technical after-sales support.
The company’s factory-direct supply model is designed to eliminate intermediary markups and provide customers with transparent and stable pricing. A comprehensive quality management system is applied throughout the entire production process, ensuring product quality remains consistent across all shipments. An established logistics network contributes to shorter delivery cycles and improved overall service reliability.
The company serves chemical manufacturers, terminal processing plants, and cross-border traders in Asia, Europe, the Americas, and the Middle East. Its core commitment is to offer high-quality, cost-effective chemical raw materials combined with professional, responsive service.
