Products Description
Loratadine is a widely‑applied non‑hormonal anti‑allergic agent categorized as a second‑generation long‑acting tricyclic antihistamine. It delivers rapid and robust pharmacological effects. Following oral absorption in humans, it is metabolized into desloratadine, its biologically more active metabolite. By competitively antagonizing histamine H1 receptors, the compound mitigates histamine‑provoked allergic responses, while exhibiting negligible anticholinergic activity and minimal central nervous system depressant effects. Clinically, it is utilized to ease manifestations of allergic rhinitis, including sneezing, rhinorrhea, nasal pruritus and ocular itching or burning sensations, as well as allergic cutaneous disorders such as chronic urticaria. From a toxicological perspective, animal‑derived investigations indicate an absence of mutagenic and teratogenic potential.
Products Chemical Properties
| Melting point | 134-136°C |
| Boiling point | 531.3±50.0 °C(Predicted) |
| density | 1.261±0.06 g/cm3(Predicted) |
| RTECS | TM6129200 |
| storage temp. | 2-8°C |
| solubility | DMSO: 26 mg/mL, soluble |
| form | powder |
| pka | 4.27±0.20(Predicted) |
| color | white |
| Water Solubility | It is soluble in DMSO (50 mg/ml), ethanol (77 mg/ml at 25°C), water (<1 mg/ml at 25°C), chloroform, and methanol. |
| Merck | 145578 |
| BCS Class | 2 |
| Stability: | Stable, but may be heat sensitive - refrigerate. Incompatible with strong oxidizing agents. |
| InChIKey | JCCNYMKQOSZNPW-UHFFFAOYSA-N |
| CAS DataBase Reference | 79794-75-5(CAS DataBase Reference) |
| EPA Substance Registry System | 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester (79794-75-5) |
Safety Information | |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| RIDADR | 3077 |
| WGK Germany | 2 |
| HS Code | 29333990 |
| Hazardous Substances Data | 79794-75-5(Hazardous Substances Data) |
Products Application
This antihistamine demonstrates high selectivity toward peripheral H1 receptors and provides powerful, prolonged therapeutic effects. As a national Class‑II new anti‑allergic agent, it is indicated for allergic arthritis, allergic rhinitis and chronic urticaria. Additionally, it alleviates both nasal and non‑nasal symptoms associated with seasonal allergic rhinitis.
Company Profile
Shandong Furuida Chemical Co., Ltd. is strategically situated in Shandong Province’s core chemical industrial zone, a location that provides access to well-established infrastructure and raw material supply networks. The company operates as a global start-up chemical foreign trade enterprise, supported by its own standardized factories that form the backbone of its integrated production and trading capabilities.
The company’s manufacturing and logistics operations are fully integrated, covering production, quality control, cross-border trade, and global logistics in a streamlined workflow. This integration enables the company to maintain independent production capacity and respond efficiently to international market demand.
The product portfolio includes basic chemical raw materials, fine intermediates, chemical additives, and rubber and plastic feedstocks, with applications spanning the rubber, plastics, coatings, daily chemicals, building materials, and textile industries. The company also provides customized products and one-stop foreign trade services, managing customs clearance, shipping, and after-sales technical support on behalf of its clients.
To address supply chain challenges such as price volatility, inconsistent quality, and delivery delays, the company has adopted a factory-direct supply model with transparent pricing, a rigorous quality control system that ensures batch-to-batch consistency, and a logistics network that supports timely delivery.
The company’s customer base includes chemical manufacturers, terminal processing plants, and cross-border traders across Asia, Europe, the Americas, and the Middle East. High-quality products, competitive pricing, and professional service form the foundation of the company’s value proposition.
