Products Description
Sulfadiazine, also referred to as diazine, is a widely‑used clinical sulfonamide anti‑infective agent. Structurally analogous to para‑aminobenzoic acid (PABA), it competes with PABA for binding to bacterial dihydrofolate synthase. Such competitive interference impedes bacterial folic acid biosynthesis with PABA as the precursor, lowering the concentration of tetrahydrofolate. As tetrahydrofolate is an indispensable compound for bacteria to synthesize purine, thymidine and DNA, this mechanism ultimately suppresses bacterial proliferation and reproduction.
This compound demonstrates inhibitory activity against susceptible pathogens including hemolytic streptococci, staphylococci, meningococci, pneumococci, gonococci, Escherichia coli and Shigella dysenteriae. It is also effective against other microorganisms such as Chlamydia trachomatis, actinomycetes, plasmodium, Nocardia asteroides and toxoplasma.
Products Chemical Properties
| Melting point | 253 °C (dec.) (lit.) |
| Boiling point | 512.6±52.0 °C(Predicted) |
| density | 1.3780 (rough estimate) |
| refractive index | 1.6440 (estimate) |
| storage temp. | 2-8°C |
| solubility | Soluble in dimethyl sulfoxide. |
| pk | pKa 2.21(H2O t = 25 I = 0.5 (NaCl)) (Uncertain) |
| form | powder |
| color | white |
| Water Solubility | 67.13mg/L(25 ºC) |
| Merck | 148903 |
| BRN | 6733588 |
| BCS Class | 45750 |
| CAS DataBase Reference | 68-35-9(CAS DataBase Reference) |
| NIST Chemistry Reference | Sulfadiazine(68-35-9) |
| EPA Substance Registry System | Benzenesulfonamide, 4-amino-N-2-pyrimidinyl- (68-35-9) |
Safety Information | |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-36/37/38-42/43-43-42 |
| Safety Statements | 26-36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | WP1925000 |
| F | 10 |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29335990 |
| Toxicity | LD50 oral in mouse: 1500mg/kg |
Products Application
As a high‑potency sulfonamide antibiotic, sulfadiazine delivers strong antibacterial and astringent properties. It features favorable therapeutic performance, fast absorption rate, slow excretion and high effective blood‑drug concentration. Clinically, it is applied for the management of infections including upper respiratory tract infection, epidemic meningitis, otitis media, furunculosis, puerperal fever, urinary tract infection and acute bacillary dysentery, mainly against pathogens such as hemolytic streptococci, pneumococci, meningococci, gonococci and Escherichia coli. Its pharmacological mode of action lies in the inhibition of prokaryotic folate biosynthesis: it suppresses dihydropteroate synthase and further blocks the generation of dihydropteroate.
Company Profile
Shandong Furuida Chemical Co., Ltd. is a global start-up chemical foreign trade enterprise based in Shandong Province's core chemical industrial zone. The company operates its own standardized manufacturing facilities, enabling full integration across production, quality control, cross-border trade, and global logistics. This integrated structure supports both independent production capacity and active participation in international markets.
The company's product portfolio includes basic chemical raw materials, fine chemical intermediates, chemical additives, and rubber and plastic feedstocks. These products are widely applied in the rubber, plastics, coatings, daily chemicals, building materials, and textile industries. In addition to standard offerings, Shandong Furuida provides customized product formulations and one-stop foreign trade services, covering customs clearance, logistics coordination, and after-sales technical support.
The company operates on a factory-direct supply model, which ensures transparent and stable pricing. A full-process quality control system maintains product consistency and reliability throughout production. Mature cross-border logistics capabilities contribute to shorter delivery cycles and improved supply chain efficiency.
