4-Dimethylaminopyridine CAS#1122-58-3

1.Powerful Acylation Catalysis – Functions as a highly effective nucleophilic acylation catalyst, markedly accelerating the acylation and esterification of alcohols, amines, and acids.

2.Exceptional Catalytic Efficiency – Delivers catalytic activity roughly 10⁴–10⁶ times greater than pyridine, enabling outstanding reaction acceleration.

3.Wide Organic Synthesis Utility – Extensively employed in organic synthesis as a reliable catalyst for acyl transfer reactions and diverse chemical transformations.

4.Chiral Asymmetric Catalysis – Chiral DMAP derivatives serve as valuable asymmetric acyl transfer catalysts, facilitating the synthesis of optically active compounds.

Products Description of 4-Dimethylaminopyridine CAS#1122-58-3

4-Dimethylaminopyridine (DMAP) is a highly effective nucleophilic acylation catalyst. The electron-donating dimethylamino group interacts with the pyridine ring through resonance, greatly enhancing the activity of the ring nitrogen atom and promoting nucleophilic substitution reactions.

DMAP can efficiently catalyze the acylation and esterification reactions of alcohols, amines, and acids, offering high catalytic efficiency with low reactivity toward unwanted side reactions. Its catalytic activity is approximately 10⁴–10⁶ times greater than that of pyridine. Acyl transfer reactions are common transformations in both natural processes and organic synthesis, and chiral DMAP is widely recognized as an important asymmetric acyl transfer catalyst.

4-Dimethylaminopyridine CAS#1122-58-3

4-Dimethylaminopyridine Chemical Properties

Melting point 112 °C
Boiling point 162 °C
density 0.906 g/mL at 25 °C
vapor pressure 0.169 hPa at 20 °C
refractive index n20/D 1.431
Fp 110 °C
storage temp. Store below +30°C.
solubility methanol: 50 mg/mL, clear
form prilled
pkapKa (20°): 9.7
color off-white to yellow
Odorcharacteristic odor
PH Range9.7 (10% aq soln)
PH11 (60g/l, H2O, 20℃)
Water Solubility 76 g/L (25 ºC)
Merck 143389
BRN 110354
Stability:Stable. Incompatible with acids, oxidizing agents.
LogP1.34 at 25℃
CAS DataBase Reference1122-58-3(CAS DataBase Reference)
NIST Chemistry Reference4-Pyridinamine, N,N-dimethyl-(1122-58-3)
EPA Substance Registry System4-(Dimethylamino)pyridine (1122-58-3)
Hazard Codes T,C,T+,Xn,F
Risk Statements 25-34-24/25-36/37/38-27-36-24-20-61-40-23/24/25-67-66-21/22-11-36/37-22-19
Safety Statements 36/37/39-45-28A-26-28-36/37-53-27-22-16
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS US8400000
Autoignition Temperature420 °C
Hazard Note Toxic/Corrosive
TSCA T
HazardClass 8
PackingGroup II

Company Profile

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