Ethylene Glycol Ethyl Ether CAS#110-80-5
2-Ethoxyethanol is a stable, colorless, flammable liquid that is synthetically produced worldwide. It belongs to the glycol ether family of solvents and is commercially known as Ethyl Cellosolve or Cellosolve, a trademark registered by Union Carbide in 1924.
2-Ethoxyethanol was originally developed to combine the chemical properties of both alcohols and ethers, providing hydrophilic and lipophilic characteristics while exhibiting lower volatility. This combination of properties helps improve production and processing characteristics.
Glycol ethers are produced by reacting anhydrous alcohols with ethylene oxide.
2-Ethoxyethanol Chemical Properties
| Melting point | -100 °C |
| Boiling point | 135 °C(lit.) |
| density | 0.93 g/mL at 25 °C(lit.) |
| vapor density | 3.1 (vs air) |
| vapor pressure | 3.8 mm Hg ( 20 °C) |
| refractive index | n20/D 1.407(lit.) |
| Fp | 107.6 °F |
| storage temp. | Store below +30°C. |
| solubility | water: miscible |
| pka | 14.44±0.10(Predicted) |
| form | Liquid |
| color | Clear, colorless |
| Odor | Sweetish; mild, pleasant, ethereal. |
| PH | 7 (20°C) |
| Odor Threshold | 0.58ppm |
| explosive limit | 1.8-15.7%(V) |
| Water Solubility | miscible |
| FreezingPoint | -70℃ |
| Thermal Conductivity | 0.169 W/(m·K) at 25 ℃ |
| λmax | λ: 215 nm Amax: 1.00 |
| λ: 225 nm Amax: 0.50 | |
| λ: 250 nm Amax: 0.20 | |
| λ: 305 nm Amax: 0.01 | |
| Merck | 143750 |
| BRN | 1098271 |
| Henry's Law Constant | 8.9×100 mol/(m3Pa) at 25℃, Johanson and Dynésius (1988) |
| Exposure limits | TLV-TWA skin 5 ppm (18.5 mg/m3) (ACGIH). . |
| Dielectric constant | 29.6(24℃) |
| Stability: | Stable. Readily forms explosive mixtures with air - note the wide explosion range. Vapour may travel considerable distance to a source of ignition. Flammable. Incompatible with strong acids, strong bases, strong oxidizing agents, aluminium, alkalies. |
| Cosmetics Ingredients Functions | SOLVENT |
| VISCOSITY CONTROLLING | |
| Cosmetic Ingredient Review (CIR) | 2-Ethoxyethanol (110-80-5) |
| InChI | 1S/C4H10O2/c1-2-6-4-3-5/h5H,2-4H2,1H3 |
| InChIKey | ZNQVEEAIQZEUHB-UHFFFAOYSA-N |
| SMILES | CCOCCO |
| LogP | 0.32 at 20℃ |
| Surface tension | 28.6mN/m at 20°C |
| CAS DataBase Reference | 110-80-5(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethanol, 2-ethoxy-(110-80-5) |
| EPA Substance Registry System | 2-Ethoxyethanol (110-80-5) |
| Hazard Codes | T |
| Risk Statements | 60-61-10-20/21/22-20/22 |
| Safety Statements | 53-45 |
| OEB | B |
| OEL | TWA: 0.5 ppm (1.8 mg/m3) [skin] |
| RIDADR | UN 1171 |
| WGK Germany | 1 |
| RTECS | KK8050000 |
| Autoignition Temperature | 460 °F |
| TSCA | TSCA listed |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29094990 |
| Storage Class | 3 - Flammable liquids |
| Hazard Classifications | Acute Tox. 3 Inhalation |
| Acute Tox. 4 Oral | |
| Flam. Liq. 3 | |
| Repr. 1B | |
| Hazardous Substances Data | 110-80-5(Hazardous Substances Data) |
| Toxicity | Acute oral LD50 for guinea pigs 1,400 mg/kg, mice 2,451 mg/kg, rats 3,000 mg/kg, rabbits 3,100 mg/kg (quoted, RTECS, 1985). |
| IDLA | 500 ppm |
Product Application of CAS#110-80-5
Ethylene glycol monoethyl ether is widely used in varnish removers and lacquers, as well as a solvent for printing inks, duplicating fluids, and epoxy materials.
Ethylene glycol monobutyl ether is used in hydraulic fluids and as a coupling agent for water-based coatings. It is also used in vinyl and acrylic paints and varnishes, as well as a solvent for varnishes, enamels, spray lacquers, dry-cleaning compounds, textiles, and cosmetics.

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