Polyethylene-Polypropylene Glycol CAS#9003-11-6
Pluronic® F-127 is a nonionic surfactant widely used to solubilize hydrophobic molecules, including cell-permeable AM esters such as Fluo-4, Fluo-8 calcium indicators, and Di-4-ANEPS / Di-8-ANEPS potentiometric probes, while facilitating their efficient loading into cells.
We provide Pluronic® F-127 as a ready-to-use 10% aqueous solution, allowing convenient use in laboratory workflows and reducing preparation steps.
A typical procedure involves using the 10% Pluronic® F-127 solution in water for loading AM ester ion indicators and other fluorescent dyes into cells. Actual loading conditions may vary depending on the cell type and the specific compounds being introduced.
Polyethylene-polypropylene glycol Chemical Properties
| Melting point | 57-61 °C |
| Boiling point | >200 °C(lit.) |
| bulk density | 1050kg/m3 |
| density | 1.095 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | <0.3 mm Hg ( 20 °C) |
| refractive index | n20/D 1.466 |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: at <70 °Csoluble |
| form | solution |
| color | APHA: ≤120, 50/50 in CH3OH |
| PH | 5.0-7.5 (100g/L in H2O) |
| PH Range | 5.0 - 7.5 |
| biological source | synthetic |
| Water Solubility | Miscible with water. |
| λmax | λ: 260 nm Amax: ≤0.3 |
| λ: 280 nm Amax: ≤0..2 | |
| Merck | 137644 |
| Hydrophilic-Lipophilic Balance (HLB) | 18 - 23 |
| Cosmetics Ingredients Functions | SURFACTANT - CLEANSING |
| SURFACTANT - HYDROTROPE | |
| CLEANSING | |
| SOLVENT | |
| HUMECTANT | |
| EMULSION STABILISING | |
| BINDING | |
| SURFACTANT - EMULSIFYING | |
| VISCOSITY CONTROLLING | |
| InChI | 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2 |
| InChIKey | RVGRUAULSDPKGF-UHFFFAOYSA-N |
| SMILES | O2C(C2)C.O1CC1 |
| LogP | -1.293 (est) |
| EPA Substance Registry System | Poloxalene (9003-11-6) |
Safety Information
| Hazard Codes | T |
| Risk Statements | 21-23/24/25-25-36/37/38 |
| Safety Statements | 23-24/25-45-36/37/39-26 |
| WGK Germany | 3 |
| RTECS | TP6164333 |
| TSCA | TSCA listed |
| Storage Class | 11 - Combustible Solids |
| Hazardous Substances Data | 9003-11-6(Hazardous Substances Data) |
| Toxicity | LD50 oral in rabbit: 35gm/kg |
Product Application of Polyethylene-Polypropylene Glycol CAS#9003-11-6
Polyethylene-polypropylene glycol is a nonionic polyoxyethylene–polyoxypropylene copolymer, primarily used in pharmaceutical formulations as an emulsifying and solubilizing agent.
Its polyoxyethylene segment is hydrophilic, while the polyoxypropylene segment is hydrophobic, giving the material excellent surface-active properties.
All grades of polyethylene-polypropylene glycol are chemically similar in composition, differing mainly in the relative proportions of ethylene oxide and propylene oxide introduced during manufacturing. As a result, their physical and surfactant properties vary over a wide range, and multiple commercial grades are available to meet different formulation requirements.
In pharmaceutical applications, it is commonly used as an emulsifier in intravenous fat emulsions, as well as a solubilizing and stabilizing agent for maintaining the clarity of elixirs and syrups.
It may also serve as a wetting agent, and is widely applied in ointments, suppository bases, gels, tablet binders, and coating systems.
Company Profile
Situated in Jinan, Shandong, Furuida (Jinan) Chemical Technology Co., Ltd. operates as a multifaceted industrial enterprise integrating chemical research, precision manufacturing, cross-border trade, and comprehensive customer support. Focused on high-value fine chemical solutions, the company upholds integrity, standardized quality systems, and lasting partnerships as its fundamental principles. Technological innovation is woven into routine production activities to drive meaningful advancements, reinforced by end-to-end quality oversight across each manufacturing stage. Through disciplined, pragmatic execution, the firm steadily expands its international footprint, refines internal processes, and strengthens worldwide brand trust.
The organization's sustained competitive edge arises from its proficient team, possessing extensive foreign trade expertise and professional technical service capabilities, complemented by a well-developed global supply chain that guarantees uniform quality and prompt order fulfillment. With yearly output exceeding RMB 600 million, Furuida has established enduring strategic alliances with over 5,000 industrial purchasers spanning Asia, Europe, Africa, and Oceania. This broad international presence has garnered significant industry acclaim and a leading position within the global chemical marketplace.
Furuida presents a varied product lineup encompassing pharmaceutical intermediates, food additives, electroplating chemicals, water treatment formulations, dye auxiliaries, advanced functional materials, titanium compounds, metal salts, catalysts, and surfactants. These adaptable industrial substances cater to numerous downstream sectors, including pharmaceutical production, electronics manufacturing, surface coatings, polymer processing, specialty chemicals, and environmental water treatment. Supported by extensive product range and strong overall capabilities, the enterprise supplies superior, economical chemical goods alongside tailored one-stop industrial solutions for clients worldwide, continuously refining service approaches to align with shifting industrial patterns and market requirements.
